ea0090oc9.2 | Oral Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023
Esposito Emanuela
, Catalano Rosa
, Nozza Emma
, Barbieri Anna Maria
, Maioli Sara
, Albrecht Ernst Geginat Jens
, Marra Giusy
, Treppiedi Donatella
, Muro Genesio Di
, Mangili Federica
, Hantel Costanze
, Palmieri Serena
, Frigerio Sofia
, Ferrante Emanuele
, Arosio Maura
, Mantovani Giovanna
, Peverelli Erika
The cytoskeletal actin-binding protein filamin A (FLNA) is poorly expressed in adrenocortical carcinomas (ACC) compared to adenomas (ACA), and this might contribute to sustain the increased cell proliferation by downregulating IGF1R expression and its downstream signaling. In mouse neural progenitor cells, increased protein expression levels of the CDK1 kinase Wee1 have been found after loss of FLNA. This protein has a leading role in regulating the G2-M checkpoint and functio...